2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W001083S1
    3-Hydroxyphenylacetic acid-d5 98%
    2-(3-Hydroxyphenyl-2,4,6-d3)acetic-2,2-d2 acid is the deuterium labeled 3-Hydroxyphenylacetic acid (HY-W001083). 3-Hydroxyphenylacetic acid is an orally active flavonoid metabolite produced by intestinal flora, with blood pressure-lowering activity. 3-Hydroxyphenylacetic acid can also inhibit ferroptosis by upregulating the expression of GPX4, thereby improving spermatogenic dysfunction in aged mice. In addition, abnormal levels of 3-Hydroxyphenylacetic acid are closely related to certain diseases, such as autism spectrum disorders.
    3-Hydroxyphenylacetic acid-d5
  • HY-W001083S2
    3-Hydroxyphenylacetic acid-d6
    3-Hydroxyphenylacetic acid-d6 is the deuterium labeled 3-Hydroxyphenylacetic acid (HY-W001083). 3-Hydroxyphenylacetic acid is an orally active flavonoid metabolite produced by intestinal flora, with blood pressure-lowering activity. 3-Hydroxyphenylacetic acid can also inhibit ferroptosis by upregulating the expression of GPX4, thereby improving spermatogenic dysfunction in aged mice. In addition, abnormal levels of 3-Hydroxyphenylacetic acid are closely related to certain diseases, such as autism spectrum disorders.
    3-Hydroxyphenylacetic acid-d6
  • HY-W001132S2
    Indole-13C8,15N 1337952-53-0 98%
    Indole-13C8,15N is the 13C and 15N labeled Indole. Indole is an endogenous metabolite.
    Indole-13C8,15N
  • HY-W001158S1
    N,N-Dimethylglycine-d3 hydrochloride 1219795-14-8 98%
    N,N-Dimethylglycine-d3 (Dimethylglycine-d3) hydrochloride is the deuterium labeled N,N-Dimethylglycine hydrochloride (HY-W001158). N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects.
    N,N-Dimethylglycine-d3 hydrochloride
  • HY-W004066S1
    Ac-Ala-OH-d4 2230887-18-8 98%
    Ac-Ala-OH-d4 is the deuterium labeled Ac-Ala-OH. Ac-Ala-OH is an endogenous metabolite.
    Ac-Ala-OH-d4
  • HY-W008820S2
    Glutaric acid-d2 43087-19-0 98%
    Glutaric acid-d2 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I.
    Glutaric acid-d2
  • HY-W009162S3
    Cytidine 5′-monophosphate-15N3,d12 dilithium 98%
    Cytidine 5′-monophosphate-15N3,d12 (5'-Cytidylic acid-15N3,d12 dilithium; 5'-CMP-15N3,d12) dilithium is deuterium and 15N labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
    Cytidine 5′-monophosphate-15N3,d12 dilithium
  • HY-W009162S4
    Cytidine 5′-monophosphate-15N3 dilithium 98%
    Cytidine 5′-monophosphate-15N3 (5'-Cytidylic acid-15N3 dilithium; 5'-CMP-15N3) dilithium is 15N labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
    Cytidine 5′-monophosphate-15N3 dilithium
  • HY-W009216S2
    2'-Deoxycytidine-5'-monophosphate-15N3,d12 dilithium 98%
    2'-Deoxycytidine-5'-monophosphoric acid-15N3,d12 dilithium is deuterium and 15N labeled 2'-Deoxycytidine-5'-monophosphoric acid (HY-W009216). 2'-Deoxycytidine-5'-monophosphoric acid is an endogenous metabolite.
    2'-Deoxycytidine-5'-monophosphate-15N3,d12 dilithium
  • HY-W009216S3
    2'-Deoxycytidine-5'-monophosphate-d12 dilithium 98%
    2'-Deoxycytidine-5'-monophosphoric acid-d12 dilithium is deuterium labeled 2'-Deoxycytidine-5'-monophosphoric acid (HY-W009216). 2'-Deoxycytidine-5'-monophosphoric acid is an endogenous metabolite.
    2'-Deoxycytidine-5'-monophosphate-d12 dilithium
  • HY-W009216S4
    2'-Deoxycytidine-5'-monophosphate-13C9 dilithium 99.5%
    2'-Deoxycytidine-5'-monophosphoric acid-13C9 dilithium is the 13C-labeled 2'-Deoxycytidine-5'-monophosphoric acid (HY-W009216). 2'-Deoxycytidine-5'-monophosphoric acid is an endogenous metabolite.
    2'-Deoxycytidine-5'-monophosphate-13C9 dilithium
  • HY-W009300S1
    4-Hydroxyestrone-13C6 98%
    4-Hydroxyestrone (4-OHE1)-13C6 is a 13C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease.
    4-Hydroxyestrone-13C6
  • HY-W010042S1
    L-Glucose-13C-1 478519-05-0 98%
    L-Glucose-13C-1 is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake.
    L-Glucose-13C-1
  • HY-W010042S2
    L-Glucose-13C-2 98%
    L-Glucose-13C-2 is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake.
    L-Glucose-13C-2
  • HY-W010104AR
    Methionine sulfoxide (Standard) 62697-73-8
    Methionine sulfoxide (Standard) is the analytical standard of Methionine sulfoxide. This product is intended for research and analytical applications. Methionine sulfoxide is an oxidation product of methionine with reactive oxygen species and can be regarded as a biomarker of oxidative stress in vivo.
    Methionine sulfoxide (Standard)
  • HY-W010452S2
    3-Hydroxybutyric acid-13C2 sodium 287389-35-9 98%
    3-Hydroxybutyric acid-13C2 (sodium) is the 13C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids.
    3-Hydroxybutyric acid-13C2 sodium
  • HY-W010589S1
    H-Abu-OH-d2 352431-37-9 98%
    H-Abu-OH-d2 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
    H-Abu-OH-d2
  • HY-W011683S1
    2'-Deoxyadenosine monohydrate-2′-13C 98%
    2'-Deoxyadenosine monohydrate-2′-13C is the 13C labeled 2'-Deoxyadenosine monohydrate(HY-W011683). 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer.
    2'-Deoxyadenosine monohydrate-2′-13C
  • HY-W011683S2
    2'-Deoxyadenosine monohydrate-3′-13C 98%
    2'-Deoxyadenosine monohydrate-3′-13C is the 13C labeled 2'-Deoxyadenosine monohydrate (HY-W011683)insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer>
    2'-Deoxyadenosine monohydrate-3′-13C
  • HY-W011683S3
    2'-Deoxyadenosine monohydrate-5′-13C 478510-77-9 98%
    2'-Deoxyadenosine monohydrate-5′-13C is the 13C labeled 2'-Deoxyadenosine monohydrate (HY-W011683). 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer.
    2'-Deoxyadenosine monohydrate-5′-13C
Cat. No. Product Name / Synonyms Application Reactivity